Assay Detail
Binding
CHEMBL2390678
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tau K19 (unknown origin) aggregation assessed as inhibition of paired helical filament formation after 10 days by thioflavin S fluorescence assay in presence of heparin
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Progress and developments in tau aggregation inhibitors for Alzheimer disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.96 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.96 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 5.96 |
| CHEMBL1527 | — | — | 1 | 5.96 |
| CHEMBL289277 | EMODIN | — | 1 | 5.96 |
| CHEMBL29898 | QUINALIZARIN | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1527 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL289277 | EMODIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL29898 | QUINALIZARIN | IC50 | = | 1100.0 | nM | 5.96 |