Assay Detail
Binding
CHEMBL2390691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of recombinant His-tagged CHK1 (unknown origin) expressed in baculovirus expression system using CDC25C and ATP as substrate after 2 hrs
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Chk1 (CHEMBL4630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Therapeutic agents triggering nonapoptotic cancer cell death.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.52 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386889 | SCH-900776 | 2.0 | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386889 | SCH-900776 | IC50 | = | 3.0 | nM | 8.52 |