Assay Detail
Binding
CHEMBL2390763
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Inhibition of human GSK3beta-mediated YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE phosphorylation
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of maleimide-based glycogen synthase kinase-3 (GSK-3) inhibitors as stimulators of steroidogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.91 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386094 | — | — | 1 | 10.89 |
| CHEMBL2386090 | — | — | 1 | 9.70 |
| CHEMBL2386093 | — | — | 1 | 9.28 |
| CHEMBL2386091 | — | — | 1 | 9.23 |
| CHEMBL2386272 | — | — | 1 | 9.06 |
| CHEMBL2386092 | — | — | 1 | 8.72 |
| CHEMBL2386088 | — | — | 1 | 8.43 |
| CHEMBL368248 | — | — | 1 | 8.38 |
| CHEMBL2386096 | — | — | 1 | 8.32 |
| CHEMBL2386112 | — | — | 1 | 8.28 |
| CHEMBL2386106 | — | — | 1 | 8.28 |
| CHEMBL2386273 | — | — | 1 | 7.95 |
| CHEMBL2386089 | — | — | 1 | 7.94 |
| CHEMBL2386097 | — | — | 1 | 7.82 |
| CHEMBL2386108 | — | — | 1 | 7.75 |
| CHEMBL2386102 | — | — | 1 | 7.70 |
| CHEMBL489422 | — | — | 1 | 7.68 |
| CHEMBL2386095 | — | — | 1 | 7.67 |
| CHEMBL2386107 | — | — | 1 | 7.60 |
| CHEMBL2386105 | — | — | 1 | 7.45 |
| CHEMBL2386103 | — | — | 1 | 7.40 |
| CHEMBL2386099 | — | — | 1 | 7.39 |
| CHEMBL2386109 | — | — | 1 | 7.24 |
| CHEMBL2386110 | — | — | 1 | 7.18 |
| CHEMBL2386104 | — | — | 1 | 7.08 |
| CHEMBL2386098 | — | — | 1 | 6.94 |
| CHEMBL2386275 | — | — | 1 | 6.94 |
| CHEMBL2386111 | — | — | 1 | 6.90 |
| CHEMBL2386274 | — | — | 1 | 6.83 |
| CHEMBL2386101 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386094 | — | IC50 | = | 0.013 | nM | 10.89 |
| CHEMBL2386090 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2386093 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL2386091 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL2386272 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL2386092 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2386088 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL368248 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL2386096 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2386112 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2386106 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2386273 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL2386089 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL2386097 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2386108 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL2386102 | — | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL489422 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL2386095 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL2386107 | — | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL2386105 | — | IC50 | = | 35.7 | nM | 7.45 |
| CHEMBL2386103 | — | IC50 | = | 39.7 | nM | 7.40 |
| CHEMBL2386099 | — | IC50 | = | 41.1 | nM | 7.39 |
| CHEMBL2386109 | — | IC50 | = | 58.2 | nM | 7.24 |
| CHEMBL2386110 | — | IC50 | = | 65.9 | nM | 7.18 |
| CHEMBL2386104 | — | IC50 | = | 82.3 | nM | 7.08 |
| CHEMBL2386098 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL2386275 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL2386111 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL2386274 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL2386101 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL2386100 | — | IC50 | = | 404.0 | nM | 6.39 |