Assay Detail
Binding
CHEMBL2390777
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Displacement of [3H]U69,593 from human recombinant kappa opioid receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.26 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440765 | U-69593 | — | 1 | 8.46 |
| CHEMBL2386901 | — | — | 1 | 7.80 |
| CHEMBL2386823 | — | — | 1 | 7.15 |
| CHEMBL2386902 | — | — | 1 | 7.10 |
| CHEMBL2386822 | — | — | 1 | 6.79 |
| CHEMBL2386821 | — | — | 1 | 6.62 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.52 |
| CHEMBL2386904 | — | — | 1 | 6.27 |
| CHEMBL2386897 | — | — | 1 | 6.17 |
| CHEMBL2386898 | — | — | 1 | 6.14 |
| CHEMBL2386896 | — | — | 1 | 6.14 |
| CHEMBL2386899 | — | — | 1 | 6.08 |
| CHEMBL2386893 | — | — | 1 | 6.01 |
| CHEMBL2386891 | — | — | 1 | 5.78 |
| CHEMBL2386903 | — | — | 1 | 5.72 |
| CHEMBL2386892 | — | — | 1 | 5.72 |
| CHEMBL2386895 | — | — | 1 | 5.65 |
| CHEMBL2386900 | — | — | 1 | 5.61 |
| CHEMBL2386894 | — | — | 1 | 5.54 |
| CHEMBL2386819 | — | — | 1 | 5.54 |
| CHEMBL2386820 | — | — | 1 | 5.45 |
| CHEMBL2386824 | — | — | 1 | 5.38 |
| CHEMBL430441 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440765 | U-69593 | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL2386901 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2386823 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL2386902 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL2386822 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL2386821 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL70 | MORPHINE | Ki | = | 299.0 | nM | 6.52 |
| CHEMBL2386904 | — | Ki | = | 541.0 | nM | 6.27 |
| CHEMBL2386897 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL2386898 | — | Ki | = | 721.0 | nM | 6.14 |
| CHEMBL2386896 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL2386899 | — | Ki | = | 826.0 | nM | 6.08 |
| CHEMBL2386893 | — | Ki | = | 971.0 | nM | 6.01 |
| CHEMBL2386891 | — | Ki | = | 1651.0 | nM | 5.78 |
| CHEMBL2386903 | — | Ki | = | 1922.0 | nM | 5.72 |
| CHEMBL2386892 | — | Ki | = | 1913.0 | nM | 5.72 |
| CHEMBL2386895 | — | Ki | = | 2217.0 | nM | 5.65 |
| CHEMBL2386900 | — | Ki | = | 2459.0 | nM | 5.61 |
| CHEMBL2386894 | — | Ki | = | 2879.0 | nM | 5.54 |
| CHEMBL2386819 | — | Ki | = | 2882.0 | nM | 5.54 |
| CHEMBL2386820 | — | Ki | = | 3544.0 | nM | 5.45 |
| CHEMBL2386824 | — | Ki | = | 4182.0 | nM | 5.38 |
| CHEMBL430441 | — | Ki | > | 5000.0 | nM | - |