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Assay Detail

CHEMBL2393619

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of beta-haematin formation after 5 to 6 hrs by UV-vis spectamax plate reader analysis
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines.
Lu WJ, Wicht KJ, Wang L, Imai K, Mei ZW, Kaiser M, El Sayed Iel T, Egan TJ, Inokuchi T.
Eur J Med Chem (2013) 64 : 498 -511
PubMed 23685569 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 4.74 5.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2391240 1 5.34
CHEMBL2391241 1 5.12
CHEMBL2391086 1 5.00
CHEMBL2391089 1 4.99
CHEMBL2391097 1 4.97
CHEMBL2391088 1 4.94
CHEMBL2391096 1 4.89
CHEMBL2391247 1 4.89
CHEMBL2391242 1 4.83
CHEMBL2391243 1 4.80
CHEMBL2391095 1 4.80
CHEMBL2391087 1 4.75
CHEMBL76 CHLOROQUINE 4.0 1 4.74
CHEMBL2391094 1 4.64
CHEMBL2391248 1 4.59
CHEMBL2391090 1 4.52
CHEMBL2391249 1 4.31
CHEMBL2391251 1 4.29
CHEMBL2391245 1 4.26
CHEMBL2391252 1 4.20
CHEMBL2391246 1 -
CHEMBL2391244 1 -
CHEMBL2391253 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2391240 IC50 = 4600.0 nM 5.34
CHEMBL2391241 IC50 = 7500.0 nM 5.12
CHEMBL2391086 IC50 = 10100.0 nM 5.00
CHEMBL2391089 IC50 = 10200.0 nM 4.99
CHEMBL2391097 IC50 = 10800.0 nM 4.97
CHEMBL2391088 IC50 = 11500.0 nM 4.94
CHEMBL2391096 IC50 = 12800.0 nM 4.89
CHEMBL2391247 IC50 = 13000.0 nM 4.89
CHEMBL2391242 IC50 = 14900.0 nM 4.83
CHEMBL2391243 IC50 = 16000.0 nM 4.80
CHEMBL2391095 IC50 = 15700.0 nM 4.80
CHEMBL2391087 IC50 = 17800.0 nM 4.75
CHEMBL76 CHLOROQUINE IC50 = 18400.0 nM 4.74
CHEMBL2391094 IC50 = 23000.0 nM 4.64
CHEMBL2391248 IC50 = 25400.0 nM 4.59
CHEMBL2391090 IC50 = 30100.0 nM 4.52
CHEMBL2391249 IC50 = 48900.0 nM 4.31
CHEMBL2391251 IC50 = 51500.0 nM 4.29
CHEMBL2391245 IC50 = 55500.0 nM 4.26
CHEMBL2391252 IC50 = 62500.0 nM 4.20
CHEMBL2391246 IC50 = 104400.0 nM -
CHEMBL2391244 IC50 = 105500.0 nM -
CHEMBL2391253 IC50 = 122800.0 nM -