Assay Detail
Binding
CHEMBL2393683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells preincubated for 10 mins prior to substrate addition measured after 4 mins by FLIPR assay
20
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.92 | 6.96 |
| IC50 | 10 | 5.53 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273575 | NOMIFENSINE | 4.0 | 2 | 6.96 |
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 2 | 6.96 |
| CHEMBL370805 | COCAINE | 4.0 | 2 | 6.60 |
| CHEMBL30713 | — | — | 2 | 6.18 |
| CHEMBL43048 | MIDOMAFETAMINE | 3.0 | 2 | 6.05 |
| CHEMBL6731 | TENAMFETAMINE | 2.0 | 2 | 5.62 |
| CHEMBL637 | VENLAFAXINE | 4.0 | 2 | 5.44 |
| CHEMBL41 | FLUOXETINE | 4.0 | 2 | 5.42 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 2 | 5.21 |
| CHEMBL2391541 | — | — | 2 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273575 | NOMIFENSINE | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL612 | DEXTROAMPHETAMINE | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL370805 | COCAINE | Ki | = | 249.0 | nM | 6.60 |
| CHEMBL273575 | NOMIFENSINE | IC50 | = | 281.84 | nM | 6.55 |
| CHEMBL612 | DEXTROAMPHETAMINE | IC50 | = | 288.4 | nM | 6.54 |
| CHEMBL370805 | COCAINE | IC50 | = | 645.65 | nM | 6.19 |
| CHEMBL30713 | — | Ki | = | 666.0 | nM | 6.18 |
| CHEMBL43048 | MIDOMAFETAMINE | Ki | = | 897.0 | nM | 6.05 |
| CHEMBL30713 | — | IC50 | = | 1862.09 | nM | 5.73 |
| CHEMBL6731 | TENAMFETAMINE | Ki | = | 2425.0 | nM | 5.62 |
| CHEMBL43048 | MIDOMAFETAMINE | IC50 | = | 2398.83 | nM | 5.62 |
| CHEMBL637 | VENLAFAXINE | Ki | = | 3620.0 | nM | 5.44 |
| CHEMBL41 | FLUOXETINE | Ki | = | 3764.0 | nM | 5.42 |
| CHEMBL6731 | TENAMFETAMINE | IC50 | = | 6165.95 | nM | 5.21 |
| CHEMBL629 | AMITRIPTYLINE | Ki | = | 6203.0 | nM | 5.21 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 9120.11 | nM | 5.04 |
| CHEMBL637 | VENLAFAXINE | IC50 | = | 9120.11 | nM | 5.04 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL2391541 | — | Ki | = | 17048.0 | nM | 4.77 |
| CHEMBL2391541 | — | IC50 | = | 32359.37 | nM | 4.49 |