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Assay Detail

CHEMBL2393722

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to JNK1 (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 8 (CHEMBL2276)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.
Gong L, Han X, Silva T, Tan YC, Goyal B, Tivitmahaisoon P, Trejo A, Palmer W, Hogg H, Jahagir A, Alam M, Wagner P, Stein K, Filonova L, Loe B, Makra F, Rotstein D, Rapatova L, Dunn J, Zuo F, Dal Porto J, Wong B, Jin S, Chang A, Tran P, Hsieh G, Niu L, Shao A, Reuter D, Hermann J, Kuglstatter A, Goldstein D.
Bioorg Med Chem Lett (2013) 23 : 3565 -3569
PubMed 23664880 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 9.85 9.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2392833 1 9.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2392833 Kd = 0.14 nM 9.85