Assay Detail
Binding
CHEMBL2393733
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Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured after 20 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SW1353 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.29 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2392831 | — | — | 1 | 6.98 |
| CHEMBL2392827 | — | — | 1 | 6.70 |
| CHEMBL2392840 | — | — | 1 | 6.66 |
| CHEMBL2392833 | — | — | 1 | 6.62 |
| CHEMBL2392832 | — | — | 1 | 6.54 |
| CHEMBL2392839 | — | — | 1 | 6.38 |
| CHEMBL2392838 | — | — | 1 | 6.19 |
| CHEMBL2392834 | — | — | 1 | 6.16 |
| CHEMBL2392825 | — | — | 1 | 6.15 |
| CHEMBL2392828 | — | — | 1 | 6.09 |
| CHEMBL2390974 | — | — | 1 | 6.00 |
| CHEMBL2392837 | — | — | 1 | 5.89 |
| CHEMBL2392835 | — | — | 1 | 5.89 |
| CHEMBL2392836 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2392831 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL2392827 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2392840 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2392833 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2392832 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2392839 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2392838 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2392834 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2392825 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2392828 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL2390974 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2392837 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2392835 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2392836 | — | IC50 | = | 1700.0 | nM | 5.77 |