Assay Detail
Binding
CHEMBL2393734
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Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by microplate scintillation counting analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.31 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2392840 | — | — | 1 | 7.92 |
| CHEMBL2392832 | — | — | 1 | 7.77 |
| CHEMBL2392833 | — | — | 1 | 7.70 |
| CHEMBL2390974 | — | — | 1 | 7.62 |
| CHEMBL2392825 | — | — | 1 | 7.62 |
| CHEMBL2392836 | — | — | 1 | 7.57 |
| CHEMBL2392838 | — | — | 1 | 7.48 |
| CHEMBL2392831 | — | — | 1 | 7.46 |
| CHEMBL2392827 | — | — | 1 | 7.44 |
| CHEMBL2392837 | — | — | 1 | 7.40 |
| CHEMBL2392834 | — | — | 1 | 7.31 |
| CHEMBL2392835 | — | — | 1 | 7.18 |
| CHEMBL2392828 | — | — | 1 | 7.17 |
| CHEMBL2392839 | — | — | 1 | 7.07 |
| CHEMBL2392826 | — | — | 1 | 6.75 |
| CHEMBL2392830 | — | — | 1 | 6.55 |
| CHEMBL2392829 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2392840 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2392832 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2392833 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2390974 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2392825 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2392836 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2392838 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2392831 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2392827 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2392837 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2392834 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2392835 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2392828 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2392839 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2392826 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2392830 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2392829 | — | IC50 | = | 650.0 | nM | 6.19 |