Assay Detail
Functional
CHEMBL2393744
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Antimalarial activity against chloroquine-resistant erythrocytic stage of Plasmodium falciparum K1 infected in human red blood cells assessed as growth inhibition after 48 hrs by [3H]-hypoxanthine incorporation assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.41 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391247 | — | — | 1 | 7.92 |
| CHEMBL2391089 | — | — | 1 | 7.80 |
| CHEMBL2391095 | — | — | 1 | 7.79 |
| CHEMBL2391087 | — | — | 1 | 7.78 |
| CHEMBL2391090 | — | — | 1 | 7.72 |
| CHEMBL2391086 | — | — | 1 | 7.71 |
| CHEMBL2391248 | — | — | 1 | 7.70 |
| CHEMBL2391246 | — | — | 1 | 7.66 |
| CHEMBL2391242 | — | — | 1 | 7.63 |
| CHEMBL2391249 | — | — | 1 | 7.52 |
| CHEMBL2391240 | — | — | 1 | 7.39 |
| CHEMBL2391241 | — | — | 1 | 7.30 |
| CHEMBL2391094 | — | — | 1 | 7.25 |
| CHEMBL2391097 | — | — | 1 | 7.19 |
| CHEMBL2391096 | — | — | 1 | 7.17 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.68 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391247 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL2391089 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL2391095 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL2391087 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL2391090 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL2391086 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL2391248 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL2391246 | — | IC50 | = | 22.1 | nM | 7.66 |
| CHEMBL2391242 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL2391249 | — | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL2391240 | — | IC50 | = | 40.8 | nM | 7.39 |
| CHEMBL2391241 | — | IC50 | = | 50.4 | nM | 7.30 |
| CHEMBL2391094 | — | IC50 | = | 56.1 | nM | 7.25 |
| CHEMBL2391097 | — | IC50 | = | 64.4 | nM | 7.19 |
| CHEMBL2391096 | — | IC50 | = | 68.4 | nM | 7.17 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 1696.0 | nM | 5.77 |