Assay Detail
Functional
CHEMBL2393747
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Antimalarial activity against chloroquine-sensitive erythrocytic stage of Plasmodium falciparum NF54 infected in human red blood cells assessed as growth inhibition after 48 hrs by [3H]-hypoxanthine incorporation assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.49 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391095 | — | — | 1 | 8.74 |
| CHEMBL2391090 | — | — | 1 | 8.67 |
| CHEMBL2391088 | — | — | 1 | 8.64 |
| CHEMBL2391094 | — | — | 1 | 8.38 |
| CHEMBL2391089 | — | — | 1 | 8.34 |
| CHEMBL2391087 | — | — | 1 | 8.25 |
| CHEMBL2391097 | — | — | 1 | 8.22 |
| CHEMBL2391086 | — | — | 1 | 8.15 |
| CHEMBL2391248 | — | — | 1 | 8.12 |
| CHEMBL2391243 | — | — | 1 | 8.09 |
| CHEMBL2391246 | — | — | 1 | 8.08 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.03 |
| CHEMBL2391247 | — | — | 1 | 8.02 |
| CHEMBL2391242 | — | — | 1 | 7.87 |
| CHEMBL2391096 | — | — | 1 | 7.84 |
| CHEMBL2391241 | — | — | 1 | 7.84 |
| CHEMBL2391240 | — | — | 1 | 7.78 |
| CHEMBL2391249 | — | — | 1 | 7.61 |
| CHEMBL2391252 | — | — | 1 | 7.48 |
| CHEMBL2391251 | — | — | 1 | 7.37 |
| CHEMBL2391250 | — | — | 1 | 7.25 |
| CHEMBL2058009 | — | — | 1 | 7.10 |
| CHEMBL2391253 | — | — | 1 | 6.56 |
| CHEMBL2391244 | — | — | 1 | 6.12 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.80 |
| CHEMBL2391091 | — | — | 1 | 5.77 |
| CHEMBL2391245 | — | — | 1 | 5.75 |
| CHEMBL2391093 | — | — | 1 | 5.67 |
| CHEMBL2391092 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391095 | — | IC50 | = | 1.81 | nM | 8.74 |
| CHEMBL2391090 | — | IC50 | = | 2.16 | nM | 8.67 |
| CHEMBL2391088 | — | IC50 | = | 2.27 | nM | 8.64 |
| CHEMBL2391094 | — | IC50 | = | 4.16 | nM | 8.38 |
| CHEMBL2391089 | — | IC50 | = | 4.54 | nM | 8.34 |
| CHEMBL2391087 | — | IC50 | = | 5.59 | nM | 8.25 |
| CHEMBL2391097 | — | IC50 | = | 6.03 | nM | 8.22 |
| CHEMBL2391086 | — | IC50 | = | 7.15 | nM | 8.15 |
| CHEMBL2391248 | — | IC50 | = | 7.57 | nM | 8.12 |
| CHEMBL2391243 | — | IC50 | = | 8.05 | nM | 8.09 |
| CHEMBL2391246 | — | IC50 | = | 8.28 | nM | 8.08 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL2391247 | — | IC50 | = | 9.52 | nM | 8.02 |
| CHEMBL2391242 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL2391096 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL2391241 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL2391240 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL2391249 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL2391252 | — | IC50 | = | 33.3 | nM | 7.48 |
| CHEMBL2391251 | — | IC50 | = | 42.5 | nM | 7.37 |
| CHEMBL2391250 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL2058009 | — | IC50 | = | 78.8 | nM | 7.10 |
| CHEMBL2391253 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL2391244 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL2391091 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL2391245 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL2391093 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL2391092 | — | IC50 | = | 2550.0 | nM | 5.59 |