Assay Detail
Binding
CHEMBL2393913
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2393431 | — | — | 1 | 6.00 |
| CHEMBL2393450 | — | — | 1 | - |
| CHEMBL2393448 | — | — | 1 | - |
| CHEMBL2393423 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2393431 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2393450 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2393448 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2393423 | — | IC50 | > | 10000.0 | nM | - |