Assay Detail
Binding
CHEMBL2394115
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Inhibition of TNFalpha-induced NF-kappa-B transcriptional activity in human K562 cells pretreated with compound for 2 hrs measured 6 hrs post TNFalpha challenge by luciferase reporter gene assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.72 | 6.10 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512054 | ALTERSOLANOL A | — | 2 | 6.10 |
| CHEMBL2392435 | — | — | 2 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512054 | ALTERSOLANOL A | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2392435 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL2392435 | — | Inhibition | - | % | - | |
| CHEMBL512054 | ALTERSOLANOL A | Inhibition | - | % | - |