Assay Detail
Functional
CHEMBL2394147
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Cytotoxicity against human SGC7901 cells assessed as growth inhibition after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SGC-7901 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of dimethylaminomethyl-substituted curcumin derivatives/analogues: potent antitumor and antioxidant activity, improved stability and aqueous solubility compared with curcumin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.67 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391734 | — | — | 1 | 5.19 |
| CHEMBL2391731 | — | — | 1 | 5.15 |
| CHEMBL2391729 | — | — | 1 | 4.63 |
| CHEMBL2391735 | — | — | 1 | 4.59 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.54 |
| CHEMBL2391736 | — | — | 1 | 4.34 |
| CHEMBL2391732 | — | — | 1 | 4.24 |
| CHEMBL2391733 | — | — | 1 | - |
| CHEMBL2391730 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391734 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2391731 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2391729 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL2391735 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL140 | CURCUMIN | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2391736 | — | IC50 | = | 45300.0 | nM | 4.34 |
| CHEMBL2391732 | — | IC50 | = | 57300.0 | nM | 4.24 |
| CHEMBL2391733 | — | IC50 | - | — | - | |
| CHEMBL2391730 | — | IC50 | = | 321100.0 | nM | - |