Assay Detail

CHEMBL2394334

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Displacement of [125I]Triiodothyronine from thyroid hormone receptor in Wistar rat liver after 18 hrs

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.

Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B.
Bioorg Med Chem Lett (2013) 23 : 1834 -1838
PubMed 23403082 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	10.74	10.74
IC50	1	10.47	10.47

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1544	LIOTHYRONINE	4.0	2	10.74

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1544	LIOTHYRONINE	Ki	=	0.018	nM	10.74
CHEMBL1544	LIOTHYRONINE	IC50	=	0.034	nM	10.47