Assay Detail
Binding
CHEMBL2394342
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Inhibition of CLK3 (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK3 (CHEMBL4226) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.57 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1877990 | — | — | 1 | 5.83 |
| CHEMBL1902528 | — | — | 1 | 5.58 |
| CHEMBL1892019 | — | — | 1 | 5.53 |
| CHEMBL1899256 | — | — | 1 | 5.49 |
| CHEMBL1898197 | — | — | 1 | 5.44 |
| CHEMBL1885748 | — | — | 1 | - |
| CHEMBL1868723 | — | — | 1 | - |
| CHEMBL1904905 | — | — | 1 | - |
| CHEMBL2392364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1877990 | — | IC50 | = | 1473.0 | nM | 5.83 |
| CHEMBL1902528 | — | IC50 | = | 2663.0 | nM | 5.58 |
| CHEMBL1892019 | — | IC50 | = | 2934.0 | nM | 5.53 |
| CHEMBL1899256 | — | IC50 | = | 3232.0 | nM | 5.49 |
| CHEMBL1898197 | — | IC50 | = | 3634.0 | nM | 5.44 |
| CHEMBL1885748 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1868723 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1904905 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2392364 | — | IC50 | > | 10000.0 | nM | - |