Assay Detail
Binding
CHEMBL2394345
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Inhibition of CLK2 (unknown origin)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK2 (CHEMBL4225) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.65 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1898197 | — | — | 1 | 7.70 |
| CHEMBL2392364 | — | — | 1 | 7.64 |
| CHEMBL1899256 | — | — | 1 | 7.52 |
| CHEMBL1904905 | — | — | 1 | 7.41 |
| CHEMBL2392365 | — | — | 1 | 7.39 |
| CHEMBL1868723 | — | — | 1 | 7.28 |
| CHEMBL1877990 | — | — | 1 | 7.22 |
| CHEMBL1892019 | — | — | 1 | 6.72 |
| CHEMBL1885748 | — | — | 1 | 6.64 |
| CHEMBL1898211 | — | — | 1 | 6.62 |
| CHEMBL1885536 | — | — | 1 | 6.59 |
| CHEMBL2392368 | — | — | 1 | 6.46 |
| CHEMBL2392360 | — | — | 1 | 6.39 |
| CHEMBL2392367 | — | — | 1 | 6.37 |
| CHEMBL1902528 | — | — | 1 | 6.33 |
| CHEMBL1884711 | — | — | 1 | 6.18 |
| CHEMBL2392359 | — | — | 1 | 5.96 |
| CHEMBL2392228 | — | — | 1 | 5.81 |
| CHEMBL1872011 | — | — | 1 | 5.72 |
| CHEMBL1882945 | — | — | 1 | 5.06 |
| CHEMBL2392362 | — | — | 1 | - |
| CHEMBL1899640 | — | — | 1 | - |
| CHEMBL1331525 | — | — | 1 | - |
| CHEMBL2392361 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1898197 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2392364 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1899256 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1904905 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2392365 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1868723 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1877990 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1892019 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1885748 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL1898211 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL1885536 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL2392368 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL2392360 | — | IC50 | = | 409.0 | nM | 6.39 |
| CHEMBL2392367 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL1902528 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL1884711 | — | IC50 | = | 665.0 | nM | 6.18 |
| CHEMBL2392359 | — | IC50 | = | 1092.0 | nM | 5.96 |
| CHEMBL2392228 | — | IC50 | = | 1557.0 | nM | 5.81 |
| CHEMBL1872011 | — | IC50 | = | 1903.0 | nM | 5.72 |
| CHEMBL1882945 | — | IC50 | = | 8791.0 | nM | 5.06 |
| CHEMBL2392362 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1899640 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1331525 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2392361 | — | IC50 | > | 10000.0 | nM | - |