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Assay Detail

CHEMBL2394447

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A2b (CHEMBL255)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides.
Inamdar GS, Pandya AN, Thakar HM, Sudarsanam V, Kachler S, Sabbadin D, Moro S, Klotz KN, Vasu KK.
Eur J Med Chem (2013) 63 : 924 -934
PubMed 23685887 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 6.20 8.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2391834 1 8.56
CHEMBL2391833 1 6.08
CHEMBL2391837 1 5.10
CHEMBL2391831 1 5.04
CHEMBL2391839 1 -
CHEMBL2391838 1 -
CHEMBL2391836 1 -
CHEMBL2391835 1 -
CHEMBL2391832 1 -
CHEMBL2391830 1 -
CHEMBL2391849 1 -
CHEMBL2391848 1 -
CHEMBL2391847 1 -
CHEMBL2391843 1 -
CHEMBL2391845 1 -
CHEMBL2391844 1 -
CHEMBL2391842 1 -
CHEMBL2391841 1 -
CHEMBL2391840 1 -
CHEMBL2391846 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2391834 Ki = 2.78 nM 8.56
CHEMBL2391833 Ki = 841.0 nM 6.08
CHEMBL2391837 Ki = 8000.0 nM 5.10
CHEMBL2391831 Ki = 9110.0 nM 5.04
CHEMBL2391839 Ki > 10000.0 nM -
CHEMBL2391838 Ki > 10000.0 nM -
CHEMBL2391836 Ki > 10000.0 nM -
CHEMBL2391835 Ki > 10000.0 nM -
CHEMBL2391832 Ki > 10000.0 nM -
CHEMBL2391830 Ki > 10000.0 nM -
CHEMBL2391849 Ki > 10000.0 nM -
CHEMBL2391848 Ki > 10000.0 nM -
CHEMBL2391847 Ki > 10000.0 nM -
CHEMBL2391843 Ki > 30000.0 nM -
CHEMBL2391845 Ki > 10000.0 nM -
CHEMBL2391844 Ki > 10000.0 nM -
CHEMBL2391842 Ki > 10000.0 nM -
CHEMBL2391841 Ki > 10000.0 nM -
CHEMBL2391840 Ki > 10000.0 nM -
CHEMBL2391846 Ki > 10000.0 nM -