Assay Detail
Binding
CHEMBL2394700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Nampt (unknown origin) after 15 mins in presence of 25 uM NAM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.15 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391568 | — | — | 1 | 7.72 |
| CHEMBL2391590 | — | — | 1 | 7.29 |
| CHEMBL2391591 | — | — | 1 | 7.09 |
| CHEMBL2391582 | — | — | 1 | 6.92 |
| CHEMBL2391550 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391568 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2391590 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2391591 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2391582 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL2391550 | — | IC50 | = | 195.0 | nM | 6.71 |