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Assay Detail

CHEMBL2394755

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [beta-33P]-2MeS-ADP from human P2Y1 receptor expressed in HEK293 cells after 1 hr by scintillation counting analysis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

P2Y purinoceptor 1 (CHEMBL4315)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

New azole antagonists with high affinity for the P2Y(1) receptor.
Ruel R, L'Heureux A, Thibeault C, Daris JP, Martel A, Price LA, Wu Q, Hua J, Wexler RR, Rehfuss R, Lam PY.
Bioorg Med Chem Lett (2013) 23 : 3519 -3522
PubMed 23668989 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 7.03 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2393201 1 8.15
CHEMBL2393200 1 8.00
CHEMBL2393213 1 7.96
CHEMBL2390979 1 7.82
CHEMBL2393211 1 7.82
CHEMBL2393206 1 7.75
CHEMBL2393219 1 7.72
CHEMBL2393207 1 7.68
CHEMBL2393220 1 7.64
CHEMBL2393214 1 7.60
CHEMBL2393202 1 7.57
CHEMBL2393210 1 7.39
CHEMBL2393196 1 7.35
CHEMBL2393203 1 7.26
CHEMBL2393212 1 7.23
CHEMBL2393216 1 7.16
CHEMBL2393195 1 7.05
CHEMBL2393204 1 6.60
CHEMBL2393209 1 6.56
CHEMBL2393208 1 6.47
CHEMBL2393217 1 6.39
CHEMBL2393205 1 6.17
CHEMBL2393198 1 6.06
CHEMBL2393215 1 5.82
CHEMBL2393218 1 5.60
CHEMBL2393199 1 5.56
CHEMBL2393194 1 5.54
CHEMBL2393197 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2393201 Ki = 7.0 nM 8.15
CHEMBL2393200 Ki = 10.0 nM 8.00
CHEMBL2393213 Ki = 11.0 nM 7.96
CHEMBL2390979 Ki = 15.0 nM 7.82
CHEMBL2393211 Ki = 15.0 nM 7.82
CHEMBL2393206 Ki = 18.0 nM 7.75
CHEMBL2393219 Ki = 19.0 nM 7.72
CHEMBL2393207 Ki = 21.0 nM 7.68
CHEMBL2393220 Ki = 23.0 nM 7.64
CHEMBL2393214 Ki = 25.0 nM 7.60
CHEMBL2393202 Ki = 27.0 nM 7.57
CHEMBL2393210 Ki = 41.0 nM 7.39
CHEMBL2393196 Ki = 45.0 nM 7.35
CHEMBL2393203 Ki = 55.0 nM 7.26
CHEMBL2393212 Ki = 59.0 nM 7.23
CHEMBL2393216 Ki = 70.0 nM 7.16
CHEMBL2393195 Ki = 90.0 nM 7.05
CHEMBL2393204 Ki = 250.0 nM 6.60
CHEMBL2393209 Ki = 275.0 nM 6.56
CHEMBL2393208 Ki = 340.0 nM 6.47
CHEMBL2393217 Ki = 410.0 nM 6.39
CHEMBL2393205 Ki = 670.0 nM 6.17
CHEMBL2393198 Ki = 870.0 nM 6.06
CHEMBL2393215 Ki = 1500.0 nM 5.82
CHEMBL2393218 Ki = 2500.0 nM 5.60
CHEMBL2393199 Ki = 2730.0 nM 5.56
CHEMBL2393194 Ki = 2900.0 nM 5.54
CHEMBL2393197 Ki > 36000.0 nM -