Assay Detail
Binding
CHEMBL2394837
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Inhibition of pig pancreas soluble alpha-amylase using 4-nitrophenyl-alpha-D-maltopentaoside as substrate after 30 mins by spectrophotometry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol diglucoside and its mammalian derivatives are potent inhibitors of α-amylase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.96 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391149 | (+)-ENTERODIOL | — | 1 | 5.07 |
| CHEMBL368347 | (+)-SECOISOLARICIRESINOL | 2.0 | 1 | 5.02 |
| CHEMBL2391150 | (+)-ENTEROLACTONE | — | 1 | 4.96 |
| CHEMBL2391148 | (+)-SECOISOLARICIRESINOLDIGLUCOSIDE | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391149 | (+)-ENTERODIOL | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL368347 | (+)-SECOISOLARICIRESINOL | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL2391150 | (+)-ENTEROLACTONE | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL2391148 | (+)-SECOISOLARICIRESINOLDIGLUCOSIDE | IC50 | = | 15700.0 | nM | 4.80 |