Assay Detail
Functional
CHEMBL2394890
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Antiproliferative activity against human HT-29 cells after 72 hrs by Cell Titer-Glo Assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.60 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2392545 | TAK-960 | 1.0 | 1 | 8.52 |
| CHEMBL2392554 | — | — | 1 | 8.30 |
| CHEMBL2392553 | — | — | 1 | 8.30 |
| CHEMBL2392558 | — | — | 1 | 8.22 |
| CHEMBL2392549 | — | — | 1 | 8.15 |
| CHEMBL2392556 | — | — | 1 | 8.10 |
| CHEMBL2392548 | — | — | 1 | 7.80 |
| CHEMBL2392544 | — | — | 1 | 7.80 |
| CHEMBL2392552 | — | — | 1 | 7.50 |
| CHEMBL2392547 | — | — | 1 | 7.40 |
| CHEMBL2392557 | — | — | 1 | 7.37 |
| CHEMBL2392551 | — | — | 1 | 7.16 |
| CHEMBL2392550 | — | — | 1 | 7.02 |
| CHEMBL2392555 | — | — | 1 | 6.75 |
| CHEMBL2392546 | — | — | 1 | 6.58 |
| CHEMBL2392543 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2392545 | TAK-960 | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2392554 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2392553 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2392558 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2392549 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2392556 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2392548 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2392544 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2392552 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2392547 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2392557 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2392551 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2392550 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL2392555 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2392546 | — | EC50 | = | 264.0 | nM | 6.58 |
| CHEMBL2392543 | — | EC50 | = | 270.0 | nM | 6.57 |