Assay Detail

CHEMBL2394931

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to P2X receptor (unknown origin) by radioligand displacement assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Cappelli A, Manini M, Valenti S, Castriconi F, Giuliani G, Anzini M, Brogi S, Butini S, Gemma S, Campiani G, Giorgi G, Mennuni L, Lanza M, Giordani A, Caselli G, Letari O, Makovec F.
Eur J Med Chem (2013) 63 : 85 -94
PubMed 23466604 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.01	9.01
IC50	1	8.68	8.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL132722	DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER	—	2	9.01

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL132722	DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER	Ki	=	0.97	nM	9.01
CHEMBL132722	DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER	IC50	=	2.1	nM	8.68