Assay Detail

CHEMBL2394932

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Binding

Binding affinity to human prostanoid EP4 receptor by radioligand displacement assay

ChEMBL ↗

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Target

Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) ↗

Open DB target context

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Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Prostaglandin E2 receptor EP4 subtype

CHEMBL1836

Anchored from Assay target.

Protein identity Prostaglandin E2 receptor EP4 subtype

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Cappelli A, Manini M, Valenti S, Castriconi F, Giuliani G, Anzini M, Brogi S, Butini S, Gemma S, Campiani G, Giorgi G, Mennuni L, Lanza M, Giordani A, Caselli G, Letari O, Makovec F.
Eur J Med Chem (2013) 63 : 85 -94
PubMed 23466604 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.77	9.77
IC50	1	9.35	9.35

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL548	DINOPROSTONE	4.0	2	9.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL548	DINOPROSTONE	Ki	=	0.17	nM	9.77
CHEMBL548	DINOPROSTONE	IC50	=	0.45	nM	9.35