Assay Detail

CHEMBL2394933

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to human PGI2 receptor by radioligand displacement assay

ChEMBL ↗

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Target

Prostacyclin receptor (CHEMBL1995) ↗

Open DB target context

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Primary target Prostacyclin receptor

CHEMBL1995

Anchored from Assay target.

Protein identity Prostacyclin receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Prostacyclin receptor (CHEMBL1995) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Cappelli A, Manini M, Valenti S, Castriconi F, Giuliani G, Anzini M, Brogi S, Butini S, Gemma S, Campiani G, Giorgi G, Mennuni L, Lanza M, Giordani A, Caselli G, Letari O, Makovec F.
Eur J Med Chem (2013) 63 : 85 -94
PubMed 23466604 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.32	8.32
IC50	1	8.08	8.08

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL494	ILOPROST	4.0	2	8.32

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL494	ILOPROST	Ki	=	4.8	nM	8.32
CHEMBL494	ILOPROST	IC50	=	8.4	nM	8.08