Assay Detail
Binding
CHEMBL2395026
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins prior to substrate addition by Ellman's method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.64 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 7.85 |
| CHEMBL2393508 | — | — | 1 | 5.92 |
| CHEMBL2393500 | — | — | 1 | 5.68 |
| CHEMBL2393498 | — | — | 1 | 5.64 |
| CHEMBL2393509 | — | — | 1 | 5.62 |
| CHEMBL2393497 | — | — | 1 | 5.54 |
| CHEMBL2393507 | — | — | 1 | 5.47 |
| CHEMBL2390982 | — | — | 1 | 5.10 |
| CHEMBL2393499 | — | — | 1 | 4.92 |
| CHEMBL2393501 | — | — | 1 | 4.67 |
| CHEMBL2390990 | — | — | 1 | - |
| CHEMBL2393513 | — | — | 1 | - |
| CHEMBL2393512 | — | — | 1 | - |
| CHEMBL2393511 | — | — | 1 | - |
| CHEMBL2393510 | — | — | 1 | - |
| CHEMBL2393505 | — | — | 1 | - |
| CHEMBL2393504 | — | — | 1 | - |
| CHEMBL2393503 | — | — | 1 | - |
| CHEMBL2393502 | — | — | 1 | - |
| CHEMBL2393506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2393508 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2393500 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2393498 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2393509 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL2393497 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2393507 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL2390982 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2393499 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL2393501 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL2390990 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393513 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393512 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393511 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393510 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393505 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393504 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393503 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393502 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2393506 | — | IC50 | > | 100000.0 | nM | - |