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Assay Detail

CHEMBL2395079

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]Rolipram from rolipram binding site in Wistar rat brain after 60 mins
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B.
Bioorg Med Chem Lett (2013) 23 : 1834 -1838
PubMed 23403082 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.68 8.68
IC50 1 8.24 8.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL63 ROLIPRAM 2.0 2 8.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL63 ROLIPRAM Ki = 2.1 nM 8.68
CHEMBL63 ROLIPRAM IC50 = 5.7 nM 8.24