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Assay Detail

CHEMBL2395085

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Platelet-activating factor receptor (CHEMBL250)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B.
Bioorg Med Chem Lett (2013) 23 : 1834 -1838
PubMed 23403082 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.82 9.82
IC50 1 9.55 9.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1235246 2 9.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1235246 Ki = 0.15 nM 9.82
CHEMBL1235246 IC50 = 0.28 nM 9.55