Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2395086

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]Glyburide from ATP-sensitive potassium channel in hamster pancreatic HIT-T15 cells after 2 hrs
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mesocricetus auratus
Cell Type HIT-T15
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B.
Bioorg Med Chem Lett (2013) 23 : 1834 -1838
PubMed 23403082 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.19 9.19
IC50 1 8.24 8.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL472 GLYBURIDE 4.0 2 9.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL472 GLYBURIDE Ki = 0.65 nM 9.19
CHEMBL472 GLYBURIDE IC50 = 5.7 nM 8.24