Assay Detail

CHEMBL2395087

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Displacement of [3H]PDBu from phorbol ester receptor in ICR mouse brain after 60 mins

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Mus musculus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.

Germain AR, Carmody LC, Nag PP, Morgan B, Verplank L, Fernandez C, Donckele E, Feng Y, Perez JR, Dandapani S, Palmer M, Lander ES, Gupta PB, Schreiber SL, Munoz B.
Bioorg Med Chem Lett (2013) 23 : 1834 -1838
PubMed 23403082 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.23	9.23
IC50	1	9.10	9.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL279115	PHORBOL MYRISTATE ACETATE	2.0	2	9.23

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL279115	PHORBOL MYRISTATE ACETATE	Ki	=	0.59	nM	9.23
CHEMBL279115	PHORBOL MYRISTATE ACETATE	IC50	=	0.79	nM	9.10