Assay Detail
Binding
CHEMBL2395155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 10 mins prior to substrate addition measured every 30 seconds for 30 mins by Ellman's method
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of the role of linker moieties in bifunctional tacrine hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.80 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2393227 | — | — | 1 | 9.30 |
| CHEMBL2393095 | — | — | 1 | 9.22 |
| CHEMBL2393097 | — | — | 1 | 9.19 |
| CHEMBL2393229 | — | — | 1 | 9.11 |
| CHEMBL2393096 | — | — | 1 | 9.03 |
| CHEMBL2393094 | — | — | 1 | 8.94 |
| CHEMBL2393109 | — | — | 1 | 8.94 |
| CHEMBL2393101 | — | — | 1 | 8.64 |
| CHEMBL2393111 | — | — | 1 | 8.53 |
| CHEMBL2393102 | — | — | 1 | 8.29 |
| CHEMBL2393093 | — | — | 1 | 8.27 |
| CHEMBL2393224 | — | — | 1 | 8.18 |
| CHEMBL2393228 | — | — | 1 | 8.16 |
| CHEMBL2393225 | — | — | 1 | 8.10 |
| CHEMBL2393226 | — | — | 1 | 7.96 |
| CHEMBL2393092 | — | — | 1 | 7.96 |
| CHEMBL2393106 | — | — | 1 | 7.87 |
| CHEMBL59782 | — | — | 1 | 7.80 |
| CHEMBL2393100 | — | — | 1 | 7.71 |
| CHEMBL2393098 | — | — | 1 | 7.58 |
| CHEMBL2393107 | — | — | 1 | 7.43 |
| CHEMBL2393090 | — | — | 1 | 7.42 |
| CHEMBL2393110 | — | — | 1 | 7.38 |
| CHEMBL2393104 | — | — | 1 | 7.37 |
| CHEMBL2393091 | — | — | 1 | 7.29 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.28 |
| CHEMBL2393099 | — | — | 1 | 7.18 |
| CHEMBL2393103 | — | — | 1 | 7.14 |
| CHEMBL2390978 | — | — | 1 | 5.86 |
| CHEMBL2393089 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2393227 | — | IC50 | = | 0.495 | nM | 9.30 |
| CHEMBL2393095 | — | IC50 | = | 0.604 | nM | 9.22 |
| CHEMBL2393097 | — | IC50 | = | 0.648 | nM | 9.19 |
| CHEMBL2393229 | — | IC50 | = | 0.776 | nM | 9.11 |
| CHEMBL2393096 | — | IC50 | = | 0.932 | nM | 9.03 |
| CHEMBL2393094 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL2393109 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL2393101 | — | IC50 | = | 2.27 | nM | 8.64 |
| CHEMBL2393111 | — | IC50 | = | 2.94 | nM | 8.53 |
| CHEMBL2393102 | — | IC50 | = | 5.17 | nM | 8.29 |
| CHEMBL2393093 | — | IC50 | = | 5.37 | nM | 8.27 |
| CHEMBL2393224 | — | IC50 | = | 6.67 | nM | 8.18 |
| CHEMBL2393228 | — | IC50 | = | 6.94 | nM | 8.16 |
| CHEMBL2393225 | — | IC50 | = | 7.91 | nM | 8.10 |
| CHEMBL2393092 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL2393226 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL2393106 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL59782 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2393100 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL2393098 | — | IC50 | = | 26.3 | nM | 7.58 |
| CHEMBL2393107 | — | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL2393090 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2393110 | — | IC50 | = | 41.7 | nM | 7.38 |
| CHEMBL2393104 | — | IC50 | = | 42.4 | nM | 7.37 |
| CHEMBL2393091 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL95 | TACRINE | IC50 | = | 52.4 | nM | 7.28 |
| CHEMBL2393099 | — | IC50 | = | 65.3 | nM | 7.18 |
| CHEMBL2393103 | — | IC50 | = | 72.5 | nM | 7.14 |
| CHEMBL2390978 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL2393089 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL2393105 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL2393108 | — | IC50 | = | 7230.0 | nM | 5.14 |