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Assay Detail

CHEMBL2395500

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human HeLa cells after 48 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and activity evaluation of tilorone analogs as potential anticancer agents.
Zhou D, Tuo W, Hu H, Xu J, Chen H, Rao Z, Xiao Y, Hu X, Liu P.
Eur J Med Chem (2013) 64 : 432 -441
PubMed 23665799 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.02 5.76

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2392994 1 5.76
CHEMBL2392988 1 5.74
CHEMBL2392995 1 5.66
CHEMBL2392993 1 5.56
CHEMBL2392889 1 5.29
CHEMBL2392890 1 5.27
CHEMBL2392987 1 5.17
CHEMBL2392996 1 5.04
CHEMBL2392985 1 4.93
CHEMBL2392986 1 4.69
CHEMBL2392979 1 4.65
CHEMBL1643105 1 4.58
CHEMBL2392888 1 4.55
CHEMBL539581 TILORONE HYDROCHLORIDE -1.0 1 4.40
CHEMBL2392980 1 4.08
CHEMBL2392992 1 -
CHEMBL2392984 1 -
CHEMBL2392983 1 -
CHEMBL2392989 1 -
CHEMBL2392990 1 -
CHEMBL2392991 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2392994 IC50 = 1720.0 nM 5.76
CHEMBL2392988 IC50 = 1820.0 nM 5.74
CHEMBL2392995 IC50 = 2210.0 nM 5.66
CHEMBL2392993 IC50 = 2730.0 nM 5.56
CHEMBL2392889 IC50 = 5170.0 nM 5.29
CHEMBL2392890 IC50 = 5320.0 nM 5.27
CHEMBL2392987 IC50 = 6780.0 nM 5.17
CHEMBL2392996 IC50 = 9170.0 nM 5.04
CHEMBL2392985 IC50 = 11730.0 nM 4.93
CHEMBL2392986 IC50 = 20230.0 nM 4.69
CHEMBL2392979 IC50 = 22180.0 nM 4.65
CHEMBL1643105 IC50 = 26390.0 nM 4.58
CHEMBL2392888 IC50 = 27840.0 nM 4.55
CHEMBL539581 TILORONE HYDROCHLORIDE IC50 = 39970.0 nM 4.40
CHEMBL2392980 IC50 = 82370.0 nM 4.08
CHEMBL2392992 IC50 > 100000.0 nM -
CHEMBL2392984 IC50 = 106630.0 nM -
CHEMBL2392983 IC50 > 100000.0 nM -
CHEMBL2392989 IC50 > 100000.0 nM -
CHEMBL2392990 IC50 > 100000.0 nM -
CHEMBL2392991 IC50 > 100000.0 nM -