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Assay Detail

CHEMBL2395737

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against PHA-stimulated human PBMC cells after 48 hrs by Alamar Blue assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type PBMC
Confidence 1 — Organism
Curated By Autocuration

Target

PBMC (CHEMBL613107)
Type CELL-LINE
Organism Homo sapiens

Publication

Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.
Mott BT, He R, Chen X, Fox JM, Civin CI, Arav-Boger R, Posner GH.
Bioorg Med Chem (2013) 21 : 3702 -3707
PubMed 23673218 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.66 6.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.57
CHEMBL219245 1 5.83
CHEMBL2393392 1 5.69
CHEMBL2393396 1 5.64
CHEMBL207675 SODIUM ARESUNATE 1 4.56
CHEMBL566534 ARTEMETHER 4.0 1 -
CHEMBL2393393 1 -
CHEMBL2393391 1 -
CHEMBL2393390 1 -
CHEMBL2393389 1 -
CHEMBL2393397 1 -
CHEMBL2393395 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 271.0 nM 6.57
CHEMBL219245 IC50 = 1477.0 nM 5.83
CHEMBL2393392 IC50 = 2031.0 nM 5.69
CHEMBL2393396 IC50 = 2281.0 nM 5.64
CHEMBL207675 SODIUM ARESUNATE IC50 = 27431.0 nM 4.56
CHEMBL566534 ARTEMETHER IC50 > 100000.0 nM -
CHEMBL2393393 IC50 > 40000.0 nM -
CHEMBL2393391 IC50 > 40000.0 nM -
CHEMBL2393390 IC50 > 40000.0 nM -
CHEMBL2393389 IC50 > 40000.0 nM -
CHEMBL2393397 IC50 > 40000.0 nM -
CHEMBL2393395 IC50 > 40000.0 nM -