Assay Detail
Functional
CHEMBL2395739
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Antiviral activity against Cytomegalovirus infected in HFF after 72 hrs by luciferase reporter gene assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cytomegalovirus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.62 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219245 | — | — | 1 | 7.41 |
| CHEMBL2393392 | — | — | 1 | 7.36 |
| CHEMBL2393389 | — | — | 1 | 7.18 |
| CHEMBL2393397 | — | — | 1 | 7.16 |
| CHEMBL2393391 | — | — | 1 | 7.15 |
| CHEMBL2393396 | — | — | 1 | 7.14 |
| CHEMBL2393395 | — | — | 1 | 7.11 |
| CHEMBL2393394 | — | — | 1 | 6.80 |
| CHEMBL2393390 | — | — | 1 | 6.52 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.57 |
| CHEMBL566534 | ARTEMETHER | 4.0 | 1 | 5.28 |
| CHEMBL207675 | SODIUM ARESUNATE | — | 1 | 4.73 |
| CHEMBL2393393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219245 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2393392 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2393389 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2393397 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2393391 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2393396 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2393395 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2393394 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2393390 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL566534 | ARTEMETHER | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL207675 | SODIUM ARESUNATE | EC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL2393393 | — | EC50 | > | 300.0 | nM | - |