Assay Detail
Binding
CHEMBL2395928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR2 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and antitumour activity of bisquinoline derivatives connected by 4-oxy-3-fluoroaniline moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.22 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 9.10 |
| CHEMBL489326 | EXELIXIS | — | 1 | 8.15 |
| CHEMBL2031893 | — | — | 1 | 8.11 |
| CHEMBL404881 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230609 | FORETINIB | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL489326 | EXELIXIS | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2031893 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL404881 | — | IC50 | = | 32.0 | nM | 7.50 |