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Assay Detail

CHEMBL2396025

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Functional
Antimalarial activity against Plasmodium falciparum 3D7 infected in O positive erythrocytes assessed as parasite lactate dehydrogenase activity after 72 hrs
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and evaluation of phenoxyoxazaphospholidine, phenoxyoxazaphosphinane, and benzodioxaphosphininamine sulfides and related compounds as potential anti-malarial agents.
Mara C, Dempsey E, Bell A, Barlow JW.
Bioorg Med Chem Lett (2013) 23 : 3580 -3583
PubMed 23659857 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 4.72 7.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2391941 1 7.42
CHEMBL236491 1 6.19
CHEMBL1835290 1 5.80
CHEMBL1256629 AMIPROPHOS METHYL 1 5.40
CHEMBL2391940 1 4.72
CHEMBL2391946 1 4.64
CHEMBL2391957 1 4.62
CHEMBL2391949 1 4.60
CHEMBL2391947 1 4.60
CHEMBL2391944 1 4.60
CHEMBL2391945 1 4.54
CHEMBL2391963 1 4.29
CHEMBL2391953 1 4.24
CHEMBL2391961 1 4.21
CHEMBL2391951 1 4.21
CHEMBL2391950 1 4.19
CHEMBL2391965 1 4.11
CHEMBL1835176 1 4.06
CHEMBL2391952 1 4.02
CHEMBL1835177 1 4.01
CHEMBL2391958 1 -
CHEMBL2391960 1 -
CHEMBL2391955 1 -
CHEMBL2391956 1 -
CHEMBL2391964 1 -
CHEMBL2391942 1 -
CHEMBL2391943 1 -
CHEMBL2391948 1 -
CHEMBL2391966 1 -
CHEMBL2391967 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2391941 IC50 = 38.0 nM 7.42
CHEMBL236491 IC50 = 640.0 nM 6.19
CHEMBL1835290 IC50 = 1600.0 nM 5.80
CHEMBL1256629 AMIPROPHOS METHYL IC50 = 4000.0 nM 5.40
CHEMBL2391940 IC50 = 19000.0 nM 4.72
CHEMBL2391946 IC50 = 23000.0 nM 4.64
CHEMBL2391957 IC50 = 24000.0 nM 4.62
CHEMBL2391949 IC50 = 25000.0 nM 4.60
CHEMBL2391947 IC50 = 25000.0 nM 4.60
CHEMBL2391944 IC50 = 25000.0 nM 4.60
CHEMBL2391945 IC50 = 29000.0 nM 4.54
CHEMBL2391963 IC50 = 51000.0 nM 4.29
CHEMBL2391953 IC50 = 58000.0 nM 4.24
CHEMBL2391961 IC50 = 62000.0 nM 4.21
CHEMBL2391951 IC50 = 62000.0 nM 4.21
CHEMBL2391950 IC50 = 64000.0 nM 4.19
CHEMBL2391965 IC50 = 77000.0 nM 4.11
CHEMBL1835176 IC50 = 87000.0 nM 4.06
CHEMBL2391952 IC50 = 95000.0 nM 4.02
CHEMBL1835177 IC50 = 98000.0 nM 4.01
CHEMBL2391958 IC50 = 108000.0 nM -
CHEMBL2391960 IC50 = 108000.0 nM -
CHEMBL2391955 IC50 = 108000.0 nM -
CHEMBL2391956 IC50 = 118000.0 nM -
CHEMBL2391964 IC50 = 128000.0 nM -
CHEMBL2391942 IC50 = 128000.0 nM -
CHEMBL2391943 IC50 = 128000.0 nM -
CHEMBL2391948 IC50 = 128000.0 nM -
CHEMBL2391966 IC50 > 128000.0 nM -
CHEMBL2391967 IC50 > 128000.0 nM -
CHEMBL2391959 IC50 > 128000.0 nM -
CHEMBL2391962 IC50 > 128000.0 nM -
CHEMBL2391954 IC50 > 128000.0 nM -