Assay Detail
Binding
CHEMBL2396178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat 11beta-HSD1
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL2391) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.33 | 8.89 |
| IC50 | 4 | 8.28 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373257 | — | — | 2 | 8.89 |
| CHEMBL1761313 | — | — | 2 | 8.41 |
| CHEMBL2391969 | — | — | 2 | 8.35 |
| CHEMBL1761321 | — | — | 2 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373257 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL373257 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1761313 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL2391969 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1761313 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2391969 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL1761321 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL1761321 | — | Ki | = | 13.1 | nM | 7.88 |