Assay Detail
Binding
CHEMBL2396181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human microsomal 11beta-HSD1 assessed as inhibition of conversion of radiolabeled cortisone to radiolabeled cortisol by cell-based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.51 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391969 | — | — | 1 | 5.51 |
| CHEMBL373257 | — | — | 1 | - |
| CHEMBL1761313 | — | — | 1 | - |
| CHEMBL1761321 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391969 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL373257 | — | IC50 | = | 2200.0 | nM | - |
| CHEMBL1761313 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL1761321 | — | IC50 | > | 4000.0 | nM | - |