Assay Detail

CHEMBL2396477

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiproliferative activity against human PC3 cells after 96 hrs

ChEMBL ↗

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Target

PC-3 (CHEMBL390) ↗

Open DB target context

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Primary target PC-3

CHEMBL390

Anchored from Assay target.

Protein identity PC-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	PC-3
Confidence	1 — Organism
Curated By	Autocuration

Target

PC-3 (CHEMBL390) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.

Gunzner-Toste J, Zhao G, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Fu B, Han B, Ho YC, Kley N, Liang X, Liederer BM, Lin J, Mukadam S, O'Brien T, Oh A, Reynolds DJ, Sharma G, Skelton N, Smith CC, Sodhi J, Wang W, Wang Z, Xiao Y, Yuen PW, Zak M, Zhang L, Zheng X, Bair KW, Dragovich PS.
Bioorg Med Chem Lett (2013) 23 : 3531 -3538
PubMed 23668988 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.83	6.83

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2393183	—	—	1	6.83

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2393183	—	IC50	=	149.0	nM	6.83