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Assay Detail

CHEMBL2399181

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Human rhinovirus 14 assessed as protection against virus-induced cytopathic effect by cell-based assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism rhinovirus B14
Confidence 1 — Organism
Curated By Autocuration

Target

rhinovirus B14 (CHEMBL613759)
Type ORGANISM
Organism rhinovirus B14

Publication

Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus.
Décor A, Grand-Maître C, Hucke O, O'Meara J, Kuhn C, Constantineau-Forget L, Brochu C, Malenfant E, Bertrand-Laperle M, Bordeleau J, Ghiro E, Pesant M, Fazal G, Gorys V, Little M, Boucher C, Bordeleau S, Turcotte P, Guo T, Garneau M, Spickler C, Gauthier A.
Bioorg Med Chem Lett (2013) 23 : 3841 -3847
PubMed 23726345 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 6.22 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2397307 1 6.66
CHEMBL2397315 1 6.54
CHEMBL2397310 1 6.54
CHEMBL2397311 1 6.49
CHEMBL2397305 1 6.39
CHEMBL2397312 1 6.35
CHEMBL2397316 1 6.33
CHEMBL2397309 1 6.30
CHEMBL2397303 1 6.19
CHEMBL2397313 1 6.14
CHEMBL2397314 1 6.00
CHEMBL2397306 1 6.00
CHEMBL2397308 1 5.97
CHEMBL2397304 1 5.78
CHEMBL2397317 1 5.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2397307 EC50 = 220.0 nM 6.66
CHEMBL2397315 EC50 = 290.0 nM 6.54
CHEMBL2397310 EC50 = 290.0 nM 6.54
CHEMBL2397311 EC50 = 325.0 nM 6.49
CHEMBL2397305 EC50 = 410.0 nM 6.39
CHEMBL2397312 EC50 = 450.0 nM 6.35
CHEMBL2397316 EC50 = 470.0 nM 6.33
CHEMBL2397309 EC50 = 500.0 nM 6.30
CHEMBL2397303 EC50 = 640.0 nM 6.19
CHEMBL2397313 EC50 = 730.0 nM 6.14
CHEMBL2397314 EC50 = 995.0 nM 6.00
CHEMBL2397306 EC50 = 990.0 nM 6.00
CHEMBL2397308 EC50 = 1080.0 nM 5.97
CHEMBL2397304 EC50 = 1650.0 nM 5.78
CHEMBL2397317 EC50 = 2300.0 nM 5.64