Assay Detail
Functional
CHEMBL2399217
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Antiprotozoal activity against intracellular amastigote form of Leishmania amazonensis infected in CD1 mouse macrophages after 72 hrs by axenic amastigote assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.32 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3215932 | — | — | 1 | 7.02 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.91 |
| CHEMBL3217248 | — | — | 1 | 6.91 |
| CHEMBL3217037 | — | — | 1 | 6.68 |
| CHEMBL3216821 | — | — | 1 | 6.04 |
| CHEMBL3217250 | — | — | 1 | 6.03 |
| CHEMBL3215933 | — | — | 1 | 5.99 |
| CHEMBL3216822 | — | — | 1 | 5.73 |
| CHEMBL3215925 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3215932 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL3217248 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL3217037 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL3216821 | — | IC50 | = | 907.0 | nM | 6.04 |
| CHEMBL3217250 | — | IC50 | = | 933.0 | nM | 6.03 |
| CHEMBL3215933 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3216822 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL3215925 | — | IC50 | = | 2430.0 | nM | 5.61 |