Assay Detail
Binding
CHEMBL2399241
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Binding affinity to human/mouse chimeric Mcl-1 by luminescence proximity assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Leukemia cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.32 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2398260 | — | — | 1 | 4.40 |
| CHEMBL2398249 | — | — | 1 | 4.38 |
| CHEMBL2398173 | — | — | 1 | 4.17 |
| CHEMBL2398290 | — | — | 1 | - |
| CHEMBL2398263 | — | — | 1 | - |
| CHEMBL2398262 | — | — | 1 | - |
| CHEMBL2398170 | — | — | 1 | - |
| CHEMBL2398286 | — | — | 1 | - |
| CHEMBL2398292 | — | — | 1 | - |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2398260 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2398249 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2398173 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL2398290 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL2398263 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2398262 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2398170 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2398286 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2398292 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL376408 | ABT 737 | IC50 | > | 1000.0 | nM | - |