Assay Detail
Binding
CHEMBL2399334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human beta-catenin expressed in Escherichia coli BL21 after 45 mins by fluorescence polarization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Direct targeting of β-catenin: Inhibition of protein-protein interactions for the inactivation of Wnt signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.92 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2397076 | — | — | 1 | 7.89 |
| CHEMBL2397077 | — | — | 1 | 7.28 |
| CHEMBL2397073 | — | — | 1 | 7.22 |
| CHEMBL2397072 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2397076 | — | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL2397077 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL2397073 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL2397072 | — | Kd | = | 5000.0 | nM | 5.30 |