Assay Detail
Binding
CHEMBL2399720
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length recombinant c-RAF (unknown origin) using MEK1 as substrate after 1 hr by luminescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.55 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2397149 | — | — | 1 | 7.52 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.35 |
| CHEMBL2397141 | — | — | 1 | 7.12 |
| CHEMBL2397146 | — | — | 1 | 6.76 |
| CHEMBL2397145 | — | — | 1 | 6.53 |
| CHEMBL2397140 | — | — | 1 | 6.47 |
| CHEMBL2397136 | — | — | 1 | 6.00 |
| CHEMBL2397137 | — | — | 1 | 5.82 |
| CHEMBL2397147 | — | — | 1 | 5.37 |
| CHEMBL1257634 | — | — | 1 | - |
| CHEMBL1946170 | REGORAFENIB | 4.0 | 1 | - |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | - |
| CHEMBL1258904 | — | — | 1 | - |
| CHEMBL2397142 | — | — | 1 | - |
| CHEMBL2397143 | — | — | 1 | - |
| CHEMBL2397144 | — | — | 1 | - |
| CHEMBL2397138 | — | — | 1 | - |
| CHEMBL242459 | — | — | 1 | - |
| CHEMBL2397148 | — | — | 1 | - |
| CHEMBL2397139 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2397149 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2397141 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2397146 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL2397145 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL2397140 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2397136 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2397137 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2397147 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1257634 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1946170 | REGORAFENIB | IC50 | - | — | - | |
| CHEMBL535 | SUNITINIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL1258904 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2397142 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2397143 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2397144 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2397138 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL242459 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2397148 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2397139 | — | IC50 | > | 10000.0 | nM | - |