Assay Detail
Binding
CHEMBL2399731
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant soluble epoxide hydrolase assessed as cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate conversion to 6-methoxy-2-naphthaldehyde preincubated for 5 mins prior to substrate addition by fluorescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 9.02 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946170 | REGORAFENIB | 4.0 | 1 | 9.30 |
| CHEMBL2397149 | — | — | 1 | 9.30 |
| CHEMBL2397137 | — | — | 1 | 9.30 |
| CHEMBL2397138 | — | — | 1 | 9.30 |
| CHEMBL2397139 | — | — | 1 | 9.30 |
| CHEMBL2397140 | — | — | 1 | 9.30 |
| CHEMBL2397147 | — | — | 1 | 9.30 |
| CHEMBL2397146 | — | — | 1 | 9.30 |
| CHEMBL2397143 | — | — | 1 | 9.30 |
| CHEMBL2397142 | — | — | 1 | 9.30 |
| CHEMBL2397141 | — | — | 1 | 9.30 |
| CHEMBL2397136 | — | — | 1 | 9.30 |
| CHEMBL2397148 | — | — | 1 | 9.05 |
| CHEMBL2397145 | — | — | 1 | 9.00 |
| CHEMBL242459 | — | — | 1 | 8.82 |
| CHEMBL1257634 | — | — | 1 | 8.54 |
| CHEMBL1258904 | — | — | 1 | 8.43 |
| CHEMBL2397144 | — | — | 1 | 8.07 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.92 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946170 | REGORAFENIB | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397149 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397137 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397138 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397139 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397140 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397147 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397146 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397143 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397142 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397141 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397136 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2397148 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2397145 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL242459 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1257634 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL1258904 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2397144 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL535 | SUNITINIB | IC50 | > | 10000.0 | nM | - |