Assay Detail
Binding
CHEMBL2399752
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Inhibition of Plasmodium falciparum falcipain-2 peptidolytic activity using Z-Phe-Arg-AMC as substrate measured over 30 mins by spectrofluorimetric analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Falcipain-2 inhibition by suramin and suramin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.13 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413246 | — | — | 1 | 7.44 |
| CHEMBL413145 | — | — | 1 | 7.38 |
| CHEMBL409304 | — | — | 1 | 7.22 |
| CHEMBL266646 | — | — | 1 | 7.21 |
| CHEMBL413910 | — | — | 1 | 7.17 |
| CHEMBL413180 | — | — | 1 | 7.11 |
| CHEMBL276295 | — | — | 1 | 7.10 |
| CHEMBL2397737 | — | — | 1 | 7.02 |
| CHEMBL2397736 | — | — | 1 | 7.01 |
| CHEMBL405500 | — | — | 1 | 6.96 |
| CHEMBL216504 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413246 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL413145 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL409304 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL266646 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL413910 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL413180 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL276295 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2397737 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL2397736 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL405500 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL216504 | — | IC50 | = | 167.0 | nM | 6.78 |