Assay Detail
Binding
CHEMBL2400724
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal myristoylated P110delta (unknown origin)-mediated AKT phosphorylation at Ser473 expressed in rat Rat1 cells by ELISA
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Rat1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.76 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2071338 | — | — | 1 | 6.21 |
| CHEMBL2397187 | — | — | 1 | 6.14 |
| CHEMBL2397189 | — | — | 1 | 6.11 |
| CHEMBL2396661 | ALPELISIB | 4.0 | 1 | 5.92 |
| CHEMBL2397193 | — | — | 1 | 5.89 |
| CHEMBL2397186 | — | — | 1 | 5.82 |
| CHEMBL2397191 | — | — | 1 | 5.80 |
| CHEMBL2397198 | — | — | 1 | 5.60 |
| CHEMBL2397196 | — | — | 1 | 5.54 |
| CHEMBL2397199 | — | — | 1 | 5.52 |
| CHEMBL2397197 | — | — | 1 | 5.31 |
| CHEMBL2397188 | — | — | 1 | 5.24 |
| CHEMBL2397195 | — | — | 1 | - |
| CHEMBL2397194 | — | — | 1 | - |
| CHEMBL2397192 | — | — | 1 | - |
| CHEMBL2397190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2071338 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2397187 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2397189 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL2396661 | ALPELISIB | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2397193 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2397186 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2397191 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2397198 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2397196 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2397199 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2397197 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL2397188 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2397195 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2397194 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2397192 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2397190 | — | IC50 | - | — | - |