Assay Detail
Binding
CHEMBL2401093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant FTase (unknown origin)-mediated K-Ras4B model peptide KKKKKKSK(Dans)TKCVIM farnesylation by fluorescence plate reader analysis in presence of FPP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.67 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2396761 | — | — | 1 | 7.82 |
| CHEMBL54279 | — | — | 1 | 6.11 |
| CHEMBL2396762 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2396761 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL54279 | — | Ki | = | 785.0 | nM | 6.11 |
| CHEMBL2396762 | — | Ki | = | 837.0 | nM | 6.08 |