Assay Detail
Binding
CHEMBL2401334
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Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells after 18 hrs by luciferase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.73 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512401 | ALTHOLACTONE | — | 1 | 5.17 |
| CHEMBL464443 | GONIOTHALAMIN | — | 1 | 4.56 |
| CHEMBL2397520 | (+)-3-O-ACETYLALTHOLACTONE | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512401 | ALTHOLACTONE | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL464443 | GONIOTHALAMIN | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL2397520 | (+)-3-O-ACETYLALTHOLACTONE | IC50 | = | 34300.0 | nM | 4.46 |