Assay Detail
Binding
CHEMBL2401355
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Competitive binding affinity to Pseudomonas aeruginosa Alg44 PilZ domain after 5 mins in presence of [32P]-c-di-GMP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2'-F-c-di-GMP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.16 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2398349 | — | — | 1 | 5.51 |
| CHEMBL1231573 | — | — | 1 | 5.11 |
| CHEMBL2398348 | — | — | 1 | 4.87 |
| CHEMBL2398347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2398349 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL1231573 | — | IC50 | = | 7690.0 | nM | 5.11 |
| CHEMBL2398348 | — | IC50 | = | 13360.0 | nM | 4.87 |
| CHEMBL2398347 | — | IC50 | > | 100000.0 | nM | - |